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Cellular Mutations and Cancer is a comprehensive scholarly work that presents cancer as a genetic, molecular, and evolutionary disease driven by the accumulation of mutations and genomic instability. The book systematically explores how alterations in oncogenes, tumor suppressor genes, and DNA repair pathways disrupt normal cellular regulation and give rise to tumor initiation, progression, metastasis, and therapeutic resistance.
Beginning with the genetic and evolutionary framework of cancer, the text explains clonal evolution, selective pressures within the tumor microenvironment, and the central role of genomic instability. It then provides an in-depth analysis of mutation types—including point mutations, insertions/deletions, chromosomal rearrangements, and epigenetic alterations—and their molecular consequences on key signaling pathways such as MAPK, PI3K–AKT, and Wnt/β-catenin.
Subsequent chapters focus on the mechanistic basis of carcinogenesis, detailing defects in DNA repair systems (BER, NER, MMR, HR, and NHEJ), chromosomal and microsatellite instability, and telomere dysfunction. The book further examines how these molecular defects promote metastasis, immune evasion, and drug resistance through Darwinian clonal selection within tumors.
The final sections emphasize modern diagnostic and therapeutic applications, including PCR, next-generation sequencing (NGS), bioinformatics, liquid biopsy, targeted therapy, and cancer immunotherapy. By integrating molecular biology, clinical oncology, and precision medicine, this work serves as an advanced educational and reference resource for graduate students, researchers, and medical professionals in cancer biology and translational medicine.
