This book includes fifteen chapters in the field of bioenergy, agriculture, energy systems, and waste from environment using reactor configurations analysis for biorefinery processes. It discusses recent biorefineries for 1G, 1.5G, 2G, and 3G sugars or ethanol from lignocellulose biomass and some unexplored feedstocks. Different process parameters governing effective biomass pretreatment and production through different bioreactors configuration such as counter-current, percolation, plug-flow, and shrinking bed in enzymatic biomass hydrolysis and fuels and chemical production. In extend to production, life cycle assessment and circular economy in biorefinery process will be getting chapters from authors. It concludes with the latest topics on biorefineries, including reactor configurations prediction through AL/ML and optimizing through AI-driven simulations and Government regulations and policies to support circular economic initiatives from strategies for the transition to advanced bioethanol production.