This book constitutes the refereed proceedings of the 5th International Conference on Innovative Technologies and Learning, ICITL 2022, held in Porto, Portugal, in August 2022. The 53 full papers presented together with 3 short papers were carefully reviewed and selected from 123 submissions. ICITL focuses on artificial intelligence in education, VR/AR/MR/XR in education, design and framework of learning systems, pedagogies to innovative technologies and learning, application and design of innovative learning.