This volume brings some of the worlds best investigators to describe recent advances in both the scientific and clinical aspects of malaria, and bridges between the two. The opening chapters discuss antimalarials and resistance to them in Africa and Asia. Then there are reviews of the different clinical manifestations of malaria, ranging from uncomplicated infections to severe disease and its complications. This section is followed by detailed reviews of what the new ‘omics’ offer to investigators of Plasmodium biology and is completed by descriptions of advances in understanding the biology of Plasmodium in the mosquito. If this volume attracts new students and provokes existing investigators to explore new directions, then it will have achieved much of what it has set out to do.