This volume contains a selection of peer reviewed most interesting extended versions of papers presented at IEEE-IS’2008 complemented with some relevant works of top people who have not attended the conference. The topics covered include virtually all areas that are considered to be relevant for the development of broadly perceived intelligent systems. They start from logical foundations, including works on classical and non-classical logics, notably fuzzy and intuitionistic fuzzy logic, and – more generally – foundations of computational intelligence and soft computing. A significant part of about 30 contributions included in this volume is concerned with intelligent autonomous agents, multi-agent systems, and ontologies. Issues related to intelligent control, intelligent knowledge discovery and data mining, and neural/fuzzy-neural networks are discussed in many papers. Intelligent decision support systems, sensor systems, group decision making and negotiations, etc. are also discussed. Much attention has been paid to a very promising direction in the area of intelligent systems, namely that of hybrid systems that through a synergistic combination of best features and strengths of particular approaches help attain a new functionality, effectiveness and efficiency.