This volume constitutes the proceedings of the 10th International Conference on Artificial Intelligence and Soft Computing, ICAISC’2010, held in Zakopane, Poland in June 13-17, 2010. The articles are organized in topical sections on Fuzzy Systems and Their Applications; Data Mining, Classification and Forecasting; Image and Speech Analysis; Bioinformatics and Medical Applications (Volume 6113) together with Neural Networks and Their Applications; Evolutionary Algorithms and Their Applications; Agent System, Robotics and Control; Various Problems aof Artificial Intelligence (Volume 6114).