Sarah and her brother live next to the world’s largest garbage dump on Staten Island in New York City. Thousands of rats at the dump have mutated into gruesome killers, and one of the workers there has just been mauled. Without mercy, the rats wreak havoc on the once-peaceful neighborhood, entering homes through kitchen sinks and toilets. Now the entire city stands on the brink of total infestation. Can the kids save millions of innocent people from a grisly death?