This book presents the 2020 Digital Platform Economy Index (DPE Index). The DPE Index integrates two separate but related literatures on ecosystems, namely, the digital ecosystem and the entrepreneurial ecosystem. This new framework situates digital entrepreneurship within the broader context of users, platforms, and institutions, such that two biotic entities (users and agents) actuate individual agency, and two abiotic components (digital infrastructure and digital platforms) form the external environment. The DPE Index framework includes 12 pillars that integrate the digital and the entrepreneurship ecosystems. Here, the authors report on the DPE Index, the four sub-indices, and the 12 pillar values for 116 countries as well as provide a cluster analysis based on the 12 pillars.