This book is a collection of peer-reviewed best selected research papers presented at the First International Conference on Machine Intelligence and Smart Systems 2020 (MISS 2020), organized during September 24–25, 2020, in Gwalior, India. The book presents new advances and research results in the fields of machine intelligence, artificial intelligence and smart systems. It includes main paradigms of machine intelligence algorithms, namely (1) neural networks, (2) evolutionary computation, (3) swarm intelligence, (4) fuzzy systems and (5) immunological computation.