This book gathers selected, extended and revised contributions to the 16th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering, and the 4th Conference on Imaging and Visualization (CMBBE 2019), held on August 14-16, 2019, in New York City, USA. It reports on cutting-edge models and algorithms for studying various tissues and organs in normal and pathological conditions; innovative imaging and visualization techniques; and the latest diagnostic tools. Further topics addressed include: numerical methods, machine learning approaches, FEM models, and high-resolution imaging and real-time visualization methods applied for biomedical purposes. Given the scope of its coverage, the book provides graduate students and researchers with a timely and insightful snapshot of the latest research and current challenges in biomedical engineering, computational biomechanics and biological imaging, as well as a source of inspiration for future research and cross-disciplinary collaborations.