This book covers the various advanced reciprocating combustion engine technologies that utilize natural gas and alternative fuels for transportation and power generation applications. It is divided into three major sections consisting of both fundamental and applied technologies to identify (but not limited to) clean, high-efficiency opportunities with natural gas fueling that have been developed through experimental protocols, numerical and high-performance computational simulations, and zero-dimensional, multizone combustion simulations. Particular emphasis is placed on statutes to monitor fine particulate emissions from tailpipe of engines operating on natural gas and alternative fuels.