This book constitutes the refereed proceedings of the 12th International Conference on Trust, Privacy and Security in Digital Business, TrustBus 2015, held in Valencia, Spain, in September 2015 in conjunction with DEXA 2015. The 17 revised full papers presented were carefully reviewed and selected from 45 submissions. The papers are organized in the following topical sections: access control; trust and reputation in pervasive environments; trust and privacy issues in mobile environments; security and privacy in the cloud; security policies/usability issues; and privacy requirements and privacy audit.