This book is a detailed review of Nuclear Medicine physics and instrumentation, including the NRC requirements for running a hot lab and a nuclear medicine division. It is meant as a review for the RISE EXAM by the American Board of Radiology. It covers hot lab equipment and its quality assurance needs, how to label and receive a radioactive package, Nuclear Medicine signage, as well as how to handle major and minor spills as well as major events and minor incidences.